Great Lakes Air is an American fixed-base operator and charter airline based in Mackinac County Airport in St. Ignace, Michigan.

Great Lakes Air began in St. Ignace, and began air charter service from Mackinac County Airport serving various destinations throughout Michigan. Over its 30-year career, Great Lakes has established a name as one of the largest air charter companies in Michigan with its main charter destination, Mackinac Island. In addition to passenger charter, cargo is also flown throughout Michigan.